Formulation and evaluation of Transdermal Patch for the treatment of Migraine

A migraine is a specific kind of headache disorder that primarily affects the head. It can range in severity from mild to severe and often accompanied by other symptoms like vomiting, nausea, illness, dizziness gets worse with movement, photophobia, sonophobia, disability, or types nature. Triptans are administered intravenously be used treat migraines irritated injection sites. Transdermal delivery means medications will through skin precise, regulated manner. Our study aims identify all possible transdermal patch combination application for treatment migraines. The drug rizatriptan belongs group drugs known as selective serotonin receptor agonists. functions constricting blood vessels brain, preventing transmission pain signals production several naturally occurring compounds produce pain, symptoms. Verapamil calcium-channel blockers. works relaxing order reduce workload heart. Lambda max Rizatriptan 278.9nm 228nm respectively. They soluble most solvents. When verapamil, rizatriptan's improves patient compliance those hypertension. P2 shows optimized results.
 Keywords: Migraine, Rizatriptan, Verapamil, Bioavailability, patch.